中文名稱：聚乙丙交酯-b-聚乙二醇-b-聚乙丙交酯(x/y/x)

英文名稱：PLGA-b-PEG-b-PLGA

PLGA-PEG-PLGA是由親水性嵌段聚乙二醇（PEG)和疏水性嵌段聚丙交酯-乙交酯（PLGA）組成(chéng)的兩(liǎng)親性BAB三嵌段共聚物。由于其優異的性能(néng)，可用于制作生物可降解溫敏水凝膠；具有可生物降解和生物相容性聚酯鏈段的聚乙二醇化共聚物還(hái)可用于制備核-殼膠束，納米顆粒和微球。産品末端的活性基團可以鏈接一些修飾多肽、蛋白、糖類、葉酸或抗體等等，使其具有主動靶向(xiàng)作用。 聚酯鏈段的水解降解能(néng)力取決于分子量和酯基（丙交酯，乙交酯或己内酯）之間的間隔基。 PEG-PLGA可以溶解在一系列常見的有機溶劑中，具體取決于其組成(chéng)，尤其是LA對(duì)GA的比例和PLGA的總分子量。随著(zhe)分子量的增加和GA含量的增加，其在普通有機溶劑中的溶解度變差。通常，較低的分子量或更高的LA含量的PEG-PLGA可以更容易地溶于氯化溶劑（如二氯甲烷或氯仿）中，有時(shí)根據總分子量溶于水可混溶的溶劑（如丙酮，乙腈和THF）中。 GA含量較高的PEG-PLGA可以更好(hǎo)地被(bèi)六氟異丙醇之類的氟化溶劑溶解。

PLGA-PEG-PLGA is an amphiphilic bab triblock copolymer composed of hydrophilic block polyethylene glycol (PEG) and hydrophobic block polylactide glycolide (PLGA). Because of its excellent properties, it can be used to prepare biodegradable thermosensitive hydrogels. Pegylated copolymers with biodegradable and biocompatible polyester segments can also be used to prepare core-shell micelles, nanoparticles and microspheres. The active group at the end of the product can link some modified peptides, proteins, sugars, folic acid or antibodies to make it have active targeting effect. The hydrolytic degradation ability of polyester segments depends on the molecular weight and the spacer between ester groups (lactide, glycolide or caprolactone). Peg-plga can be dissolved in a series of common organic solvents, depending on its composition, especially the ratio of La to GA and the total molecular weight of PLGA. With the increase of molecular weight and GA content, its solubility in ordinary organic solvents becomes worse. Generally, peg-plga with lower molecular weight or higher La content can be more easily dissolved in chlorinated solvents (such as dichloromethane or chloroform), and sometimes in water miscible solvents (such as acetone, acetonitrile and THF) according to the total molecular weight. Peg-plga with higher GA content can be better dissolved by fluorinated solvents such as hexafluoroisopropanol.